{"response":{"status":"ok","message_type":"publication"},"id":175,"citation":"Hellemans et al., 2005, Antimicrobial Agents and Chemotherapy","doi":"10.1128/aac.49.11.4530-4535.2005","url":"https://api.seqco.de/v1/publications/175.json","link_ext":"https://doi.org/10.1128/aac.49.11.4530-4535.2005","title":"Evaluation of Antibiotic Treatment against “\n            \u003ci\u003eCandidatus\u003c/i\u003e\n            Helicobacter suis” in a Mouse Model","journal":"Antimicrobial Agents and Chemotherapy","journal_loc":"49 (11)","journal_date":"2005-11-01","pub_type":"journal-article","abstract":"\u003cjats:title\u003eABSTRACT\u003c/jats:title\u003e\n          \u003cjats:p\u003e\n            “\n            \u003cjats:italic\u003eHelicobacter\nheilmannii\u003c/jats:italic\u003e\n            ” (proposed name) type 1 colonizes\nthe human stomach. It has been shown to be identical to“\n            \u003cjats:italic\u003eCandidatus\u003c/jats:italic\u003e\n            Helicobacter suis,” a\n            \u003cjats:italic\u003eHelicobacter\u003c/jats:italic\u003e\n            species colonizing the stomachs of \u0026gt;60%\nof slaughter pigs. This bacterium has not been isolated in vitro until\nnow. Antibiotic susceptibility testing of “\n            \u003cjats:italic\u003eCandidatus\u003c/jats:italic\u003e\n            Helicobacter suis” has not been carried out so far. For the\npresent study, a mouse model was adopted to evaluate the antibiotic\nsusceptibility of this organism. Mice infected with“\n            \u003cjats:italic\u003eCandidatus\u003c/jats:italic\u003e\n            Helicobacter suis” were treated\nwith amoxicillin and omeprazole, a therapy which is used to treat\n            \u003cjats:italic\u003eH. heilmannii\u003c/jats:italic\u003e\n            infections in humans. Two different isolates of“\n            \u003cjats:italic\u003eCandidatus\u003c/jats:italic\u003e\n            Helicobacter suis” were tested.\nThe excretion of bacterial DNA was assessed during treatment, using PCR\non fecal samples. At the end of the experiment, 8 days after the\ncessation of treatment, the presence of infection was evaluated using a\nurease test and a PCR test on stomach samples. A marked decrease in the\nexcretion of bacterial DNA was observed a few days after the onset of\ntreatment, and the level remained low until the end of the experiment.\nA difference in susceptibility between the two“\n            \u003cjats:italic\u003eCandidatus\u003c/jats:italic\u003e\n            Helicobacter suis” isolates was\npointed out. The in vivo mouse model infected with“\n            \u003cjats:italic\u003eCandidatus\u003c/jats:italic\u003e\n            Helicobacter suis” will be useful\nfor further screening of potential therapeutic\nregimens.\n          \u003c/jats:p\u003e","long_citation_html":"Hellemans et al. (2005). Evaluation of Antibiotic Treatment against “\n            \u003ci\u003eCandidatus\u003c/i\u003e\n            Helicobacter suis” in a Mouse Model. \n\u003ci\u003eAntimicrobial Agents and Chemotherapy\u003c/i\u003e. \u003ca href=\"https://doi.org/10.1128/aac.49.11.4530-4535.2005\" target=\"_blank\"\u003eDOI:10.1128/aac.49.11.4530-4535.2005\u003c/a\u003e\n","created_at":"2019-04-15T18:46:10.960Z","updated_at":"2025-11-06T11:27:08.197Z","authors":[{"id":568,"given":"A.","family":"Hellemans","created_at":"2019-04-15T18:46:10.972Z","updated_at":"2019-04-15T18:46:10.972Z","url":"https://api.seqco.de/v1/authors/568.json"},{"id":569,"given":"A.","family":"Decostere","created_at":"2019-04-15T18:46:10.982Z","updated_at":"2019-04-15T18:46:10.982Z","url":"https://api.seqco.de/v1/authors/569.json"},{"id":280,"given":"F.","family":"Haesebrouck","created_at":"2019-04-15T18:46:01.080Z","updated_at":"2019-04-15T18:46:01.080Z","url":"https://api.seqco.de/v1/authors/280.json"},{"id":276,"given":"R.","family":"Ducatelle","created_at":"2019-04-15T18:46:01.037Z","updated_at":"2019-04-15T18:46:01.037Z","url":"https://api.seqco.de/v1/authors/276.json"}],"names":[{"id":182,"name":"Candidatus Helicobacter suis","url":"https://api.seqco.de/v1/names/182.json","uri":"https://seqco.de/i:182"}],"subjects":[{"id":17,"name":"Infectious Diseases","url":"https://api.seqco.de/v1/subjects/17.json"},{"id":20,"name":"Pharmacology","url":"https://api.seqco.de/v1/subjects/20.json"},{"id":19,"name":"Pharmacology (medical)","url":"https://api.seqco.de/v1/subjects/19.json"}]}