{"response":{"status":"ok","message_type":"publication"},"id":2384,"citation":"Hua et al., 2019, Nature Communications","doi":"10.1038/s41467-019-12574-y","url":"https://api.seqco.de/v1/publications/2384.json","link_ext":"https://doi.org/10.1038/s41467-019-12574-y","title":"Insights into the ecological roles and evolution of methyl-coenzyme M reductase-containing hot spring Archaea","journal":"Nature Communications","journal_loc":"10 (1)","journal_date":"2019-10-08","pub_type":"journal-article","abstract":"\u003cjats:title\u003eAbstract\u003c/jats:title\u003e\u003cjats:p\u003eSeveral recent studies have shown the presence of genes for the key enzyme associated with archaeal methane/alkane metabolism, methyl-coenzyme M reductase (Mcr), in metagenome-assembled genomes (MAGs) divergent to existing archaeal lineages. Here, we study the \u003cjats:italic\u003emcr\u003c/jats:italic\u003e-containing archaeal MAGs from several hot springs, which reveal further expansion in the diversity of archaeal organisms performing methane/alkane metabolism. Significantly, an MAG basal to organisms from the phylum \u003cjats:italic\u003eThaumarchaeota\u003c/jats:italic\u003e that contains \u003cjats:italic\u003emcr\u003c/jats:italic\u003e genes, but not those for ammonia oxidation or aerobic metabolism, is identified. Together, our phylogenetic analyses and ancestral state reconstructions suggest a mostly vertical evolution of \u003cjats:italic\u003emcrABG\u003c/jats:italic\u003e genes among methanogens and methanotrophs, along with frequent horizontal gene transfer of \u003cjats:italic\u003emcr\u003c/jats:italic\u003e genes between alkanotrophs. Analysis of all \u003cjats:italic\u003emcr\u003c/jats:italic\u003e-containing archaeal MAGs/genomes suggests a hydrothermal origin for these microorganisms based on optimal growth temperature predictions. These results also suggest methane/alkane oxidation or methanogenesis at high temperature likely existed in a common archaeal ancestor.\u003c/jats:p\u003e","long_citation_html":"Hua et al. (2019). Insights into the ecological roles and evolution of methyl-coenzyme M reductase-containing hot spring Archaea.\n\u003ci\u003eNature Communications\u003c/i\u003e.\n\u003ca href=\"https://doi.org/10.1038/s41467-019-12574-y\" target=\"_blank\"\u003eDOI: 10.1038/s41467-019-12574-y\u003c/a\u003e\n","created_at":"2021-11-05T00:22:13.254Z","updated_at":"2025-11-06T13:52:01.305Z","authors":[{"id":7324,"given":"Zheng-Shuang","family":"Hua","created_at":"2020-03-29T06:30:53.942Z","updated_at":"2020-03-29T06:30:53.942Z","url":"https://api.seqco.de/v1/authors/7324.json"},{"id":9168,"given":"Yu-Lin","family":"Wang","created_at":"2021-11-05T00:22:13.314Z","updated_at":"2021-11-05T00:22:13.314Z","url":"https://api.seqco.de/v1/authors/9168.json"},{"id":8669,"given":"Paul N.","family":"Evans","created_at":"2021-07-05T06:39:43.605Z","updated_at":"2021-07-05T06:39:43.605Z","url":"https://api.seqco.de/v1/authors/8669.json"},{"id":7319,"given":"Yan-Ni","family":"Qu","created_at":"2020-03-29T06:30:52.233Z","updated_at":"2020-03-29T06:30:52.233Z","url":"https://api.seqco.de/v1/authors/7319.json"},{"id":9169,"given":"Kian Mau","family":"Goh","created_at":"2021-11-05T00:22:13.344Z","updated_at":"2021-11-05T00:22:13.344Z","url":"https://api.seqco.de/v1/authors/9169.json"},{"id":7317,"given":"Yang-Zhi","family":"Rao","created_at":"2020-03-29T06:30:51.607Z","updated_at":"2020-03-29T06:30:51.607Z","url":"https://api.seqco.de/v1/authors/7317.json"},{"id":7318,"given":"Yan-Ling","family":"Qi","created_at":"2020-03-29T06:30:51.874Z","updated_at":"2020-03-29T06:30:51.874Z","url":"https://api.seqco.de/v1/authors/7318.json"},{"id":7316,"given":"Yu-Xian","family":"Li","created_at":"2020-03-29T06:30:51.249Z","updated_at":"2020-03-29T06:30:51.249Z","url":"https://api.seqco.de/v1/authors/7316.json"},{"id":9170,"given":"Min-Jun","family":"Huang","created_at":"2021-11-05T00:22:13.382Z","updated_at":"2021-11-05T00:22:13.382Z","url":"https://api.seqco.de/v1/authors/9170.json"},{"id":7321,"given":"Jian-Yu","family":"Jiao","created_at":"2020-03-29T06:30:52.866Z","updated_at":"2020-03-29T06:30:52.866Z","url":"https://api.seqco.de/v1/authors/7321.json"},{"id":7320,"given":"Ya-Ting","family":"Chen","created_at":"2020-03-29T06:30:52.492Z","updated_at":"2020-03-29T06:30:52.492Z","url":"https://api.seqco.de/v1/authors/7320.json"},{"id":9171,"given":"Yan-Ping","family":"Mao","created_at":"2021-11-05T00:22:13.412Z","updated_at":"2021-11-05T00:22:13.412Z","url":"https://api.seqco.de/v1/authors/9171.json"},{"id":6411,"given":"Wen-Sheng","family":"Shu","created_at":"2019-04-15T19:30:27.552Z","updated_at":"2019-04-15T19:30:27.552Z","url":"https://api.seqco.de/v1/authors/6411.json"},{"id":9172,"given":"Wael","family":"Hozzein","created_at":"2021-11-05T00:22:13.440Z","updated_at":"2021-11-05T00:22:13.440Z","url":"https://api.seqco.de/v1/authors/9172.json"},{"id":4371,"given":"Brian P.","family":"Hedlund","created_at":"2019-04-15T19:26:29.383Z","updated_at":"2019-04-15T19:26:29.383Z","url":"https://api.seqco.de/v1/authors/4371.json"},{"id":6176,"given":"Gene W.","family":"Tyson","created_at":"2019-04-15T19:30:14.105Z","updated_at":"2019-04-15T19:30:14.105Z","url":"https://api.seqco.de/v1/authors/6176.json"},{"id":2189,"given":"Tong","family":"Zhang","created_at":"2019-04-15T18:47:13.634Z","updated_at":"2019-04-15T18:47:13.634Z","url":"https://api.seqco.de/v1/authors/2189.json"},{"id":6408,"given":"Wen-Jun","family":"Li","created_at":"2019-04-15T19:30:27.501Z","updated_at":"2019-04-15T19:30:27.501Z","url":"https://api.seqco.de/v1/authors/6408.json"}],"names":[{"id":23636,"name":"Candidatus Methanoproducendum senex","url":"https://api.seqco.de/v1/names/23636.json","uri":"https://seqco.de/i:23636"}],"subjects":[{"id":13,"name":"General Biochemistry, Genetics and Molecular Biology","url":"https://api.seqco.de/v1/subjects/13.json"},{"id":12,"name":"General Chemistry","url":"https://api.seqco.de/v1/subjects/12.json"},{"id":83,"name":"General Physics and Astronomy","url":"https://api.seqco.de/v1/subjects/83.json"}]}