{"response":{"status":"ok","message_type":"publication"},"id":3027,"citation":"Li et al., 2023, Frontiers in Plant Science","doi":"10.3389/fpls.2023.1204305","url":"https://api.seqco.de/v1/publications/3027.json","link_ext":"https://doi.org/10.3389/fpls.2023.1204305","title":"Metabolic changes and potential biomarkers in \"Candidatus Liberibacter solanacearum\"-infected potato psyllids: implications for psyllid-pathogen interactions","journal":"Frontiers in Plant Science","journal_loc":"14","journal_date":"2023-07-19","pub_type":"journal-article","abstract":"\u003cjats:p\u003ePsyllid yellows, vein-greening (VG), and zebra chip (ZC) diseases, which are primarily transmitted by potato psyllid (PoP) carrying \u003cjats:italic\u003eCandidatus\u003c/jats:italic\u003e Liberibacter solanacearum (\u003cjats:italic\u003eC\u003c/jats:italic\u003eLso), have caused significant losses in solanaceous crop production worldwide. Pathogens interact with their vectors at the organic and cellular levels, while the potential changes that may occur at the biochemical level are less well reported. In this study, the impact of \u003cjats:italic\u003eC\u003c/jats:italic\u003eLso on the metabolism of PoP and the identification of biomarkers from infected psyllids were examined. Using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) analysis, metabolomic changes in \u003cjats:italic\u003eC\u003c/jats:italic\u003eLso-infected psyllids were compared to uninfected ones. A total of 34 metabolites were identified as potential biomarkers of \u003cjats:italic\u003eC\u003c/jats:italic\u003eLso infection, which were primarily related to amino acid, carbohydrate, and lipid metabolism. The significant increase in glycerophospholipids is thought to be associated with \u003cjats:italic\u003eC\u003c/jats:italic\u003eLso evading the insect vector’s immune defense. Matrix-assisted Laser Desorption Ionization Mass Spectrometry Imaging (MALDI-MSI) was used to map the spatial distribution of these biomarkers, revealing that 15-keto-Prostaglandin E2 and alpha-D-Glucose were highly expressed in the abdomen of uninfected psyllids but down-regulated in infected psyllids. It is speculated that this down-regulation may be due to \u003cjats:italic\u003eC\u003c/jats:italic\u003eLso evading surveillance by immune suppression in the PoP midgut. Overall, valuable biochemical information was provided, a theoretical basis for a better understanding of psyllid-pathogen interactions was offered, and the findings may aid in breaking the transmission cycle of these diseases.\u003c/jats:p\u003e","long_citation_html":"Li et al. (2023). Metabolic changes and potential biomarkers in \u0026quot;Candidatus Liberibacter solanacearum\u0026quot;-infected potato psyllids: implications for psyllid-pathogen interactions. \n\u003ci\u003eFrontiers in Plant Science\u003c/i\u003e. \u003ca href=\"https://doi.org/10.3389/fpls.2023.1204305\" target=\"_blank\"\u003eDOI:10.3389/fpls.2023.1204305\u003c/a\u003e\n","created_at":"2023-07-20T22:00:16.886Z","updated_at":"2025-11-06T14:16:35.068Z","authors":[{"id":12004,"given":"Yelin","family":"Li","created_at":"2023-07-20T22:00:16.914Z","updated_at":"2023-07-20T22:00:16.914Z","url":"https://api.seqco.de/v1/authors/12004.json"},{"id":12005,"given":"Zhiqing","family":"Tan","created_at":"2023-07-20T22:00:16.937Z","updated_at":"2023-07-20T22:00:16.937Z","url":"https://api.seqco.de/v1/authors/12005.json"},{"id":12006,"given":"Xiaolan","family":"Wang","created_at":"2023-07-20T22:00:16.945Z","updated_at":"2023-07-20T22:00:16.945Z","url":"https://api.seqco.de/v1/authors/12006.json"},{"id":12007,"given":"Liping","family":"Hou","created_at":"2023-07-20T22:00:16.953Z","updated_at":"2023-07-20T22:00:16.953Z","url":"https://api.seqco.de/v1/authors/12007.json"}],"names":[{"id":34,"name":"Liberibacter solanacearum","url":"https://api.seqco.de/v1/names/34.json","uri":"https://seqco.de/i:34"}],"subjects":[{"id":24,"name":"Plant Science","url":"https://api.seqco.de/v1/subjects/24.json"}]}