{"response":{"status":"ok","message_type":"publication"},"id":3173,"citation":"Chibani et al., 2021, Nature Microbiology","doi":"10.1038/s41564-021-01020-9","url":"https://api.seqco.de/v1/publications/3173.json","link_ext":"https://doi.org/10.1038/s41564-021-01020-9","title":"A catalogue of 1,167 genomes from the human gut archaeome","journal":"Nature Microbiology","journal_loc":"7 (1)","journal_date":"2021-12-30","pub_type":"journal-article","abstract":"\u003cjats:title\u003eAbstract\u003c/jats:title\u003e\u003cjats:p\u003eThe human gut microbiome plays an important role in health, but its archaeal diversity remains largely unexplored. In the present study, we report the analysis of 1,167 nonredundant archaeal genomes (608 high-quality genomes) recovered from human gastrointestinal tract, sampled across 24 countries and rural and urban populations. We identified previously undescribed taxa including 3 genera, 15 species and 52 strains. Based on distinct genomic features, we justify the split of the\u003cjats:italic\u003eMethanobrevibacter smithii\u003c/jats:italic\u003eclade into two separate species, with one represented by the previously undescribed ‘\u003cjats:italic\u003eCandidatus\u003c/jats:italic\u003e\u003cjats:italic\u003eMethanobrevibacter intestini\u003c/jats:italic\u003e’. Patterns derived from 28,581 protein clusters showed significant associations with sociodemographic characteristics such as age groups and lifestyle. We additionally show that archaea are characterized by specific genomic and functional adaptations to the host and carry a complex virome. Our work expands our current understanding of the human archaeome and provides a large genome catalogue for future analyses to decipher its impact on human physiology.\u003c/jats:p\u003e","long_citation_html":"Chibani et al. (2021). A catalogue of 1,167 genomes from the human gut archaeome. \n\u003ci\u003eNature Microbiology\u003c/i\u003e. \u003ca href=\"https://doi.org/10.1038/s41564-021-01020-9\" target=\"_blank\"\u003eDOI:10.1038/s41564-021-01020-9\u003c/a\u003e\n","created_at":"2023-08-30T22:04:27.675Z","updated_at":"2025-11-06T14:18:08.011Z","authors":[{"id":12626,"given":"Cynthia Maria","family":"Chibani","created_at":"2023-08-30T22:04:27.739Z","updated_at":"2023-08-30T22:04:27.739Z","url":"https://api.seqco.de/v1/authors/12626.json"},{"id":12627,"given":"Alexander","family":"Mahnert","created_at":"2023-08-30T22:04:27.751Z","updated_at":"2023-08-30T22:04:27.751Z","url":"https://api.seqco.de/v1/authors/12627.json"},{"id":9392,"given":"Guillaume","family":"Borrel","created_at":"2021-12-15T16:49:55.751Z","updated_at":"2021-12-15T16:49:55.751Z","url":"https://api.seqco.de/v1/authors/9392.json"},{"id":12628,"given":"Alexandre","family":"Almeida","created_at":"2023-08-30T22:04:27.769Z","updated_at":"2023-08-30T22:04:27.769Z","url":"https://api.seqco.de/v1/authors/12628.json"},{"id":12629,"given":"Almut","family":"Werner","created_at":"2023-08-30T22:04:27.779Z","updated_at":"2023-08-30T22:04:27.779Z","url":"https://api.seqco.de/v1/authors/12629.json"},{"id":9403,"given":"Jean-François","family":"Brugère","created_at":"2021-12-15T16:49:55.926Z","updated_at":"2021-12-15T16:49:55.926Z","url":"https://api.seqco.de/v1/authors/9403.json"},{"id":8885,"given":"Simonetta","family":"Gribaldo","created_at":"2021-08-23T08:40:38.763Z","updated_at":"2021-08-23T08:40:38.763Z","url":"https://api.seqco.de/v1/authors/8885.json"},{"id":12630,"given":"Robert D.","family":"Finn","created_at":"2023-08-30T22:04:27.802Z","updated_at":"2023-08-30T22:04:27.802Z","url":"https://api.seqco.de/v1/authors/12630.json"},{"id":12631,"given":"Ruth A.","family":"Schmitz","created_at":"2023-08-30T22:04:27.812Z","updated_at":"2023-08-30T22:04:27.812Z","url":"https://api.seqco.de/v1/authors/12631.json"},{"id":8886,"given":"Christine","family":"Moissl-Eichinger","created_at":"2021-08-23T08:40:38.785Z","updated_at":"2021-08-23T08:40:38.785Z","url":"https://api.seqco.de/v1/authors/8886.json"}],"names":[{"id":32532,"name":"Methanarcanum hacksteinii","url":"https://api.seqco.de/v1/names/32532.json","uri":"https://seqco.de/i:32532"},{"id":32534,"name":"Methanoprimaticola hominis","url":"https://api.seqco.de/v1/names/32534.json","uri":"https://seqco.de/i:32534"},{"id":32535,"name":"Methanoprimaticola","url":"https://api.seqco.de/v1/names/32535.json","uri":"https://seqco.de/i:32535"},{"id":32780,"name":"Methanarcanum","url":"https://api.seqco.de/v1/names/32780.json","uri":"https://seqco.de/i:32780"},{"id":44139,"name":"Methanobrevibacter intestini","url":"https://api.seqco.de/v1/names/44139.json","uri":"https://seqco.de/i:44139"}],"subjects":[{"id":23,"name":"Applied Microbiology and Biotechnology","url":"https://api.seqco.de/v1/subjects/23.json"},{"id":30,"name":"Cell Biology","url":"https://api.seqco.de/v1/subjects/30.json"},{"id":15,"name":"Genetics","url":"https://api.seqco.de/v1/subjects/15.json"},{"id":10,"name":"Immunology","url":"https://api.seqco.de/v1/subjects/10.json"},{"id":9,"name":"Microbiology","url":"https://api.seqco.de/v1/subjects/9.json"},{"id":8,"name":"Microbiology (medical)","url":"https://api.seqco.de/v1/subjects/8.json"}]}