{"response":{"status":"ok","message_type":"publication"},"id":3697,"citation":"Li et al., 2024, eLife","doi":"10.7554/elife.93450.3","url":"https://api.seqco.de/v1/publications/3697.json","link_ext":"https://doi.org/10.7554/elife.93450.3","title":"Adipokinetic hormone signaling mediates the enhanced fecundity of Diaphorina citri infected by ‘Candidatus Liberibacter asiaticus’","journal":"eLife","journal_loc":"13","journal_date":"2024-07-10","pub_type":"journal-article","abstract":"\u003cjats:p\u003e\u003cjats:italic\u003eDiaphorina citri\u003c/jats:italic\u003e serves as the primary vector for ‘\u003cjats:italic\u003eCandidatus\u003c/jats:italic\u003e Liberibacter asiaticus (\u003cjats:italic\u003eC\u003c/jats:italic\u003eLas),’ the bacterium associated with the severe Asian form of huanglongbing. \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas-positive \u003cjats:italic\u003eD. citri\u003c/jats:italic\u003e are more fecund than their \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas-negative counterparts and require extra energy expenditure. Therefore, understanding the molecular mechanisms linking metabolism and reproduction is of particular importance. In this study, we found adipokinetic hormone (\u003cjats:italic\u003eDcAKH\u003c/jats:italic\u003e) and its receptor (\u003cjats:italic\u003eDcAKHR\u003c/jats:italic\u003e) were essential for increasing lipid metabolism and fecundity in response to \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas infection in \u003cjats:italic\u003eD. citri\u003c/jats:italic\u003e. Knockdown of \u003cjats:italic\u003eDcAKH\u003c/jats:italic\u003e and \u003cjats:italic\u003eDcAKHR\u003c/jats:italic\u003e not only resulted in the accumulation of triacylglycerol and a decline of glycogen, but also significantly decreased fecundity and \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas titer in ovaries. Combined in vivo and in vitro experiments showed that miR-34 suppresses \u003cjats:italic\u003eDcAKHR\u003c/jats:italic\u003e expression by binding to its 3’ untranslated region, whilst overexpression of miR-34 resulted in a decline of \u003cjats:italic\u003eDcAKHR\u003c/jats:italic\u003e expression and \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas titer in ovaries and caused defects that mimicked \u003cjats:italic\u003eDcAKHR\u003c/jats:italic\u003e knockdown phenotypes. Additionally, knockdown of \u003cjats:italic\u003eDcAKH\u003c/jats:italic\u003e and \u003cjats:italic\u003eDcAKHR\u003c/jats:italic\u003e significantly reduced juvenile hormone (JH) titer and JH signaling pathway genes in fat bodies and ovaries, including the JH receptor, \u003cjats:italic\u003emethoprene-tolerant\u003c/jats:italic\u003e (\u003cjats:italic\u003eDcMet\u003c/jats:italic\u003e), and the transcription factor, \u003cjats:italic\u003eKrüppel homolog 1 (DcKr-h1\u003c/jats:italic\u003e), that acts downstream of it, as well as the egg development related genes \u003cjats:italic\u003evitellogenin 1-like\u003c/jats:italic\u003e (\u003cjats:italic\u003eDcVg-1-like\u003c/jats:italic\u003e), \u003cjats:italic\u003evitellogenin A1-like\u003c/jats:italic\u003e (\u003cjats:italic\u003eDcVg-A1-like\u003c/jats:italic\u003e) and the vitellogenin receptor (\u003cjats:italic\u003eDcVgR\u003c/jats:italic\u003e). As a result, \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas hijacks AKH/AKHR-miR-34-JH signaling to improve \u003cjats:italic\u003eD. citri\u003c/jats:italic\u003e lipid metabolism and fecundity, while simultaneously increasing the replication of \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas, suggesting a mutualistic interaction between \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas and \u003cjats:italic\u003eD. citri\u003c/jats:italic\u003e ovaries.\u003c/jats:p\u003e","long_citation_html":"Li et al. (2024). Adipokinetic hormone signaling mediates the enhanced fecundity of Diaphorina citri infected by ‘Candidatus Liberibacter asiaticus’. \n\u003ci\u003eeLife\u003c/i\u003e. \u003ca href=\"https://doi.org/10.7554/elife.93450.3\" target=\"_blank\"\u003eDOI:10.7554/elife.93450.3\u003c/a\u003e\n","created_at":"2024-07-11T22:00:19.141Z","updated_at":"2025-11-06T11:21:56.401Z","authors":[{"id":11655,"given":"Jiayun","family":"Li","created_at":"2023-05-20T22:00:17.224Z","updated_at":"2023-05-20T22:00:17.224Z","url":"https://api.seqco.de/v1/authors/11655.json"},{"id":5570,"given":"Paul","family":"Holford","created_at":"2019-04-15T19:29:33.367Z","updated_at":"2019-04-15T19:29:33.367Z","url":"https://api.seqco.de/v1/authors/5570.json"},{"id":6701,"given":"George Andrew Charles","family":"Beattie","created_at":"2019-08-25T06:31:04.162Z","updated_at":"2019-08-25T06:31:04.162Z","url":"https://api.seqco.de/v1/authors/6701.json"},{"id":11654,"given":"Shujie","family":"Wu","created_at":"2023-05-20T22:00:17.216Z","updated_at":"2023-05-20T22:00:17.216Z","url":"https://api.seqco.de/v1/authors/11654.json"},{"id":11657,"given":"Jielan","family":"He","created_at":"2023-05-20T22:00:17.239Z","updated_at":"2023-05-20T22:00:17.239Z","url":"https://api.seqco.de/v1/authors/11657.json"},{"id":11658,"given":"Shijian","family":"Tan","created_at":"2023-05-20T22:00:17.248Z","updated_at":"2023-05-20T22:00:17.248Z","url":"https://api.seqco.de/v1/authors/11658.json"},{"id":11659,"given":"Desen","family":"Wang","created_at":"2023-05-20T22:00:17.255Z","updated_at":"2023-05-20T22:00:17.255Z","url":"https://api.seqco.de/v1/authors/11659.json"},{"id":5571,"given":"Yurong","family":"He","created_at":"2019-04-15T19:29:33.376Z","updated_at":"2019-04-15T19:29:33.376Z","url":"https://api.seqco.de/v1/authors/5571.json"},{"id":5454,"given":"Yijing","family":"Cen","created_at":"2019-04-15T19:29:30.542Z","updated_at":"2019-04-15T19:29:30.542Z","url":"https://api.seqco.de/v1/authors/5454.json"},{"id":11653,"given":"Xiaoge","family":"Nian","created_at":"2023-05-20T22:00:17.208Z","updated_at":"2023-05-20T22:00:17.208Z","url":"https://api.seqco.de/v1/authors/11653.json"}],"names":[{"id":1,"name":"Candidatus Liberibacter asiaticus","url":"https://api.seqco.de/v1/names/1.json","uri":"https://seqco.de/i:1"}],"subjects":[]}