{"response":{"status":"ok","message_type":"publication"},"id":4141,"citation":"Yuan et al., 2025, Pest Management Science","doi":"10.1002/ps.70032","url":"https://api.seqco.de/v1/publications/4141.json","link_ext":"https://doi.org/10.1002/ps.70032","title":"The autophagy pathway participates in resistance to \u003ci\u003eCandidatus\u003c/i\u003e Liberibacter asiaticus infection in \u003ci\u003eDiaphorina citri\u003c/i\u003e","journal":"Pest Management Science","journal_loc":"81 (10)","journal_date":"2025-10-01","pub_type":"journal-article","abstract":"\u003cjats:title\u003eAbstract\u003c/jats:title\u003e\u003cjats:sec\u003e\u003cjats:title\u003eBACKGROUND\u003c/jats:title\u003e\u003cjats:p\u003eAutophagy is a conserved mechanism by which eukaryotic organisms defend against pathogen infection. However, the molecular mechanisms underlying the role of autophagy in the interactions of insect vectors with the phloem‐limited bacterial pathogen remain unclear. The citrus Huanglongbing (HLB)‐associated pathogen ‘\u003cjats:italic\u003eCandidatus\u003c/jats:italic\u003e Liberibacter asiaticus’ (\u003cjats:italic\u003eC\u003c/jats:italic\u003eLas) seriously endangers development of the citrus industry. It spreads via \u003cjats:italic\u003eDiaphorina citri\u003c/jats:italic\u003e in a persistent and propagative manner.\u003c/jats:p\u003e\u003c/jats:sec\u003e\u003cjats:sec\u003e\u003cjats:title\u003eRESULTS\u003c/jats:title\u003e\u003cjats:p\u003eIn this study, a total of 30 autophagy‐related genes (ATG) were identified in the \u003cjats:italic\u003eD. citri\u003c/jats:italic\u003e genome, among which multiple genes were significantly regulated after \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas infection. Concurrently, \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas infection also leads to an increased number of autophagosomes and enhanced accumulation of ATG8‐II. Ultrastructural observations revealed the presence of bacterial‐like structures within autophagosomes in the midgut of \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas‐infected \u003cjats:italic\u003eD. citri\u003c/jats:italic\u003e. Furthermore, both activation and inhibition of autophagy significantly influenced \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas titers. However, autophagy cannot completely eliminate \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas in \u003cjats:italic\u003eD. citri\u003c/jats:italic\u003e. We identified a \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas effector, SDE4040 (CLIBASIA_04040), that interacts with \u003cjats:italic\u003eDc\u003c/jats:italic\u003eATG8 and co‐localizes on autophagosomes in \u003cjats:italic\u003eD. citri\u003c/jats:italic\u003e. Co‐expression of SDE4040 and \u003cjats:italic\u003eDc\u003c/jats:italic\u003eATG8 induces autophagy in \u003cjats:italic\u003eSpodoptera frugiperda\u003c/jats:italic\u003e (Sf9) cells.\u003c/jats:p\u003e\u003c/jats:sec\u003e\u003cjats:sec\u003e\u003cjats:title\u003eCONCLUSION\u003c/jats:title\u003e\u003cjats:p\u003eTaken together, these results indicate that \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas infection activates the autophagy pathway in \u003cjats:italic\u003eD. citri\u003c/jats:italic\u003e, contributing to a reduction in bacterial titer. Our data also revealed that \u003cjats:italic\u003eC\u003c/jats:italic\u003eLas may trigger complex interactions with the insect. © 2025 Society of Chemical Industry.\u003c/jats:p\u003e\u003c/jats:sec\u003e","long_citation_html":"Yuan et al. (2025). The autophagy pathway participates in resistance to \u003ci\u003eCandidatus\u003c/i\u003e Liberibacter asiaticus infection in \u003ci\u003eDiaphorina citri\u003c/i\u003e. \n\u003ci\u003ePest Management Science\u003c/i\u003e. \u003ca href=\"https://doi.org/10.1002/ps.70032\" target=\"_blank\"\u003eDOI:10.1002/ps.70032\u003c/a\u003e\n","created_at":"2025-08-02T22:00:26.398Z","updated_at":"2025-11-06T11:16:41.119Z","authors":[{"id":11539,"given":"Yingzhe","family":"Yuan","created_at":"2023-04-19T22:01:09.836Z","updated_at":"2023-04-19T22:01:09.836Z","url":"https://api.seqco.de/v1/authors/11539.json"},{"id":11538,"given":"Tao","family":"Peng","created_at":"2023-04-19T22:01:09.820Z","updated_at":"2023-04-19T22:01:09.820Z","url":"https://api.seqco.de/v1/authors/11538.json"},{"id":16390,"given":"Caifu","family":"Liu","created_at":"2025-08-02T22:00:26.447Z","updated_at":"2025-08-02T22:00:26.447Z","url":"https://api.seqco.de/v1/authors/16390.json"},{"id":16391,"given":"Xiaochun","family":"Wang","created_at":"2025-08-02T22:00:26.458Z","updated_at":"2025-08-02T22:00:26.458Z","url":"https://api.seqco.de/v1/authors/16391.json"},{"id":7262,"given":"Xuejin","family":"Cui","created_at":"2020-03-01T07:30:39.423Z","updated_at":"2020-03-01T07:30:39.423Z","url":"https://api.seqco.de/v1/authors/7262.json"},{"id":11540,"given":"Chenyang","family":"Yuan","created_at":"2023-04-19T22:01:09.870Z","updated_at":"2023-04-19T22:01:09.870Z","url":"https://api.seqco.de/v1/authors/11540.json"},{"id":13784,"given":"Tianyuan","family":"Liu","created_at":"2024-03-23T23:00:29.963Z","updated_at":"2024-03-23T23:00:29.963Z","url":"https://api.seqco.de/v1/authors/13784.json"},{"id":16392,"given":"Li","family":"Xie","created_at":"2025-08-02T22:00:26.486Z","updated_at":"2025-08-02T22:00:26.486Z","url":"https://api.seqco.de/v1/authors/16392.json"},{"id":7283,"given":"Long","family":"Yi","created_at":"2020-03-15T06:30:50.497Z","updated_at":"2020-03-15T06:30:50.497Z","url":"https://api.seqco.de/v1/authors/7283.json"},{"id":453,"given":"Changyong","family":"Zhou","created_at":"2019-04-15T18:46:08.019Z","updated_at":"2019-04-15T18:46:08.019Z","url":"https://api.seqco.de/v1/authors/453.json"},{"id":452,"given":"Xuefeng","family":"Wang","created_at":"2019-04-15T18:46:07.997Z","updated_at":"2019-04-15T18:46:07.997Z","url":"https://api.seqco.de/v1/authors/452.json"}],"names":[{"id":1,"name":"Candidatus Liberibacter asiaticus","url":"https://api.seqco.de/v1/names/1.json","uri":"https://seqco.de/i:1"}],"subjects":[]}