{"response":{"status":"ok","message_type":"publication"},"id":4485,"citation":"Liu et al., 2026, Advanced Science","doi":"10.1002/advs.202517056","url":"https://api.seqco.de/v1/publications/4485.json","link_ext":"https://doi.org/10.1002/advs.202517056","title":"Genome‐Wide Association Study Reveals Insect Genetics and Microbial Symbiont Effects on Susceptibility of\n                    \u003ci\u003eDiaphorina citri\u003c/i\u003e\n                    to the Citrus Greening Pathogen,\n                    \u003ci\u003eCandidatus\u003c/i\u003e\n                    Liberibacter Asiaticus","journal":"Advanced Science","journal_loc":"13 (29)","journal_date":"2026-05-01","pub_type":"journal-article","abstract":"\u003cjats:title\u003eABSTRACT\u003c/jats:title\u003e\n                  \u003cjats:p\u003e\n                    Insect‐vectored pathogens pose a significant threat to global agriculture. The colonization efficiency of pathogens in vectors plays a central role in these pathosystems, yet studies of the factors that affect this aspect are limited. This study investigates the genetic and microbial symbiont factors influencing the susceptibility of\n                    \u003cjats:italic\u003eDiaphorina citri\u003c/jats:italic\u003e\n                    to\n                    \u003cjats:italic\u003eCandidatus\u003c/jats:italic\u003e\n                    Liberibacter asiaticus (\n                    \u003cjats:italic\u003eC\u003c/jats:italic\u003e\n                    Las), the pathogen causing citrus greening disease (huanglongbing). Through a microbiome Genome Wide Association Study (mGWAS) based on 16S amplicon sequencing and genomic resequencing of 120\n                    \u003cjats:italic\u003eD. citri\u003c/jats:italic\u003e\n                    individuals from six populations, we identified 79 SNPs significantly associated with the relative abundance of\n                    \u003cjats:italic\u003eC\u003c/jats:italic\u003e\n                    Las within insects. Additionally, some of these SNPs were also associated with the relative abundance of\n                    \u003cjats:italic\u003eCandidatus\u003c/jats:italic\u003e\n                    Profftella armature, a key endosymbiont of\n                    \u003cjats:italic\u003eD. citri\u003c/jats:italic\u003e\n                    . SNPs in the regulatory region of gene\n                    \u003cjats:italic\u003eDcitr04g11610.1\u003c/jats:italic\u003e\n                    led to its overexpression in\n                    \u003cjats:italic\u003eC\u003c/jats:italic\u003e\n                    Las‐susceptible\n                    \u003cjats:italic\u003eD. citri\u003c/jats:italic\u003e\n                    , and\n                    \u003cjats:italic\u003eC\u003c/jats:italic\u003e\n                    Las infection further elevated its expression. Conversely, RNAi knockdown of\n                    \u003cjats:italic\u003eDcitr04g11610.1\u003c/jats:italic\u003e\n                    reduced\n                    \u003cjats:italic\u003eC\u003c/jats:italic\u003e\n                    Las infection rates and abundance, accompanied by increased abundance of\n                    \u003cjats:italic\u003eProfftella\u003c/jats:italic\u003e\n                    . Phylogenetic analysis revealed\n                    \u003cjats:italic\u003eDcitr04g11610.1\u003c/jats:italic\u003e\n                    ’s high homology to Major Facilitator Superfamily‐type transporter SLC18B1 proteins, suggesting a role in\n                    \u003cjats:italic\u003eC\u003c/jats:italic\u003e\n                    Las polyamine utilization. These findings highlight the importance and potential interplay of insect genetics and symbiotic microbiota in insect‐vectored plant pathogen systems.\n                  \u003c/jats:p\u003e","long_citation_html":"Liu et al. (2026). Genome‐Wide Association Study Reveals Insect Genetics and Microbial Symbiont Effects on Susceptibility of\n                    \u003ci\u003eDiaphorina citri\u003c/i\u003e\n                    to the Citrus Greening Pathogen,\n                    \u003ci\u003eCandidatus\u003c/i\u003e\n                    Liberibacter Asiaticus. \n\u003ci\u003eAdvanced Science\u003c/i\u003e. \u003ca href=\"https://doi.org/10.1002/advs.202517056\" target=\"_blank\"\u003eDOI:10.1002/advs.202517056\u003c/a\u003e\n","created_at":"2026-03-12T00:00:11.515Z","updated_at":"2026-06-10T00:00:17.800Z","authors":[{"id":8254,"given":"Kai","family":"Liu","created_at":"2021-03-18T08:44:15.457Z","updated_at":"2021-03-18T08:44:15.457Z","url":"https://api.seqco.de/v1/authors/8254.json"},{"id":18265,"given":"Qingcui","family":"He","created_at":"2026-03-12T00:00:11.561Z","updated_at":"2026-03-12T00:00:11.561Z","url":"https://api.seqco.de/v1/authors/18265.json"},{"id":18266,"given":"Zeyue","family":"Lin","created_at":"2026-03-12T00:00:11.573Z","updated_at":"2026-03-12T00:00:11.573Z","url":"https://api.seqco.de/v1/authors/18266.json"},{"id":18267,"given":"Shixuan","family":"Huang","created_at":"2026-03-12T00:00:11.584Z","updated_at":"2026-03-12T00:00:11.584Z","url":"https://api.seqco.de/v1/authors/18267.json"},{"id":18268,"given":"Zichun","family":"Zhong","created_at":"2026-03-12T00:00:11.596Z","updated_at":"2026-03-12T00:00:11.596Z","url":"https://api.seqco.de/v1/authors/18268.json"},{"id":18269,"given":"Pingyang","family":"Zhu","created_at":"2026-03-12T00:00:11.607Z","updated_at":"2026-03-12T00:00:11.607Z","url":"https://api.seqco.de/v1/authors/18269.json"},{"id":18270,"given":"Mengge","family":"Gao","created_at":"2026-03-12T00:00:11.619Z","updated_at":"2026-03-12T00:00:11.619Z","url":"https://api.seqco.de/v1/authors/18270.json"},{"id":18271,"given":"Luyao","family":"Zhao","created_at":"2026-03-12T00:00:11.630Z","updated_at":"2026-03-12T00:00:11.630Z","url":"https://api.seqco.de/v1/authors/18271.json"},{"id":18272,"given":"Han","family":"Jin","created_at":"2026-03-12T00:00:11.641Z","updated_at":"2026-03-12T00:00:11.641Z","url":"https://api.seqco.de/v1/authors/18272.json"},{"id":18273,"given":"Guiting","family":"Wu","created_at":"2026-03-12T00:00:11.657Z","updated_at":"2026-03-12T00:00:11.657Z","url":"https://api.seqco.de/v1/authors/18273.json"},{"id":18274,"given":"Gurr M.","family":"Geoff","created_at":"2026-03-12T00:00:11.668Z","updated_at":"2026-03-12T00:00:11.668Z","url":"https://api.seqco.de/v1/authors/18274.json"},{"id":8259,"given":"Qunxin","family":"Han","created_at":"2021-03-18T08:44:15.521Z","updated_at":"2021-03-18T08:44:15.521Z","url":"https://api.seqco.de/v1/authors/8259.json"},{"id":8258,"given":"Rui","family":"Pang","created_at":"2021-03-18T08:44:15.508Z","updated_at":"2021-03-18T08:44:15.508Z","url":"https://api.seqco.de/v1/authors/8258.json"}],"names":[{"id":1,"name":"Candidatus Liberibacter asiaticus","url":"https://api.seqco.de/v1/names/1.json","uri":"https://seqco.de/i:1"},{"id":10973,"name":"Liberibacter","url":"https://api.seqco.de/v1/names/10973.json","uri":"https://seqco.de/i:10973"},{"id":55882,"name":"Candidatus Profftella armature","url":"https://api.seqco.de/v1/names/55882.json","uri":"https://seqco.de/i:55882"}],"subjects":[]}