{"response":{"status":"ok","message_type":"publication"},"id":4988,"citation":"Bohr et al., 2003, Helicobacter","doi":"10.1111/j.1523-5378.2003.00186.x","url":"https://api.seqco.de/v1/publications/4988.json","link_ext":"https://doi.org/10.1111/j.1523-5378.2003.00186.x","title":"Detection of a Putative Novel \u003ci\u003eWolinella\u003c/i\u003e Species in Patients with Squamous Cell Carcinoma of the Esophagus","journal":"Helicobacter","journal_loc":"8 (6)","journal_date":"2003-12-01","pub_type":"journal-article","abstract":"\u003cjats:title\u003eABSTRACT\u003c/jats:title\u003e\u003cjats:p\u003e\u003cjats:bold\u003eBackground. \u003c/jats:bold\u003e Certain regions of South Africa exhibit an extraordinarily high incidence of esophageal carcinoma that develops via an esophagitis–dysplasia–carcinoma sequence. Bacteria belonging to the family \u003cjats:italic\u003eHelicobacteraceae\u003c/jats:italic\u003e are candidates for involvement in the initiation of the esophagitis. We investigated patients with esophageal carcinoma for the occurrence of \u003cjats:italic\u003eHelicobacter\u003c/jats:italic\u003e‐related species\u003cjats:italic\u003e.\u003c/jats:italic\u003e\u003c/jats:p\u003e\u003cjats:p\u003e\u003cjats:bold\u003eMethods. \u003c/jats:bold\u003e Biopsies from tumor and nonlesional tissue of the esophagus from nine patients with squamous cell carcinoma were investigated for \u003cjats:italic\u003eHelicobacteraceae\u003c/jats:italic\u003e using a PCR‐based method targeting the 16S rRNA gene.\u003c/jats:p\u003e\u003cjats:p\u003e\u003cjats:bold\u003eResults. \u003c/jats:bold\u003e Four out of nine patients tested negative, while samples from the other five patients revealed an infection by different \u003cjats:italic\u003eHelicobacter\u003c/jats:italic\u003e species. Sequence analysis of the PCR fragments led to the identification of a hitherto unknown bacterium in three of these patients. Phylogenetically, this bacterium was assigned to the genus \u003cjats:italic\u003eWolinella\u003c/jats:italic\u003e within the family of \u003cjats:italic\u003eHelicobacteraceae\u003c/jats:italic\u003e. \u003cjats:italic\u003eHelicobacter pylori\u003c/jats:italic\u003e was identified in three patients, and one revealed a coinfection with the novel \u003cjats:italic\u003eWolinella\u003c/jats:italic\u003e species.\u003c/jats:p\u003e\u003cjats:p\u003e\u003cjats:bold\u003eConclusions. \u003c/jats:bold\u003e  \u003cjats:italic\u003eHelicobacteraceae\u003c/jats:italic\u003e were detected in approximately 50% of South African patients with esophageal carcinoma. Furthermore, a novel bacterium was identified that might be linked to the enhanced incidence of esophagitis and subsequent malignant disease in South Africa.\u003c/jats:p\u003e","long_citation_html":"Bohr et al. (2003). Detection of a Putative Novel \u003ci\u003eWolinella\u003c/i\u003e Species in Patients with Squamous Cell Carcinoma of the Esophagus.\n\u003ci\u003eHelicobacter\u003c/i\u003e.\n\u003ca href=\"https://doi.org/10.1111/j.1523-5378.2003.00186.x\" target=\"_blank\"\u003eDOI: 10.1111/j.1523-5378.2003.00186.x\u003c/a\u003e\n","created_at":"2026-11-08T12:08:21.996Z","updated_at":"2026-11-09T00:00:22.019Z","authors":[{"id":20122,"given":"Ulrich R. M.","family":"Bohr","created_at":"2026-11-08T12:08:22.079Z","updated_at":"2026-11-08T12:08:22.079Z","url":"https://api.seqco.de/v1/authors/20122.json"},{"id":20123,"given":"Isidor","family":"Segal","created_at":"2026-11-08T12:08:22.170Z","updated_at":"2026-11-08T12:08:22.170Z","url":"https://api.seqco.de/v1/authors/20123.json"},{"id":20124,"given":"Anett","family":"Primus","created_at":"2026-11-08T12:08:22.182Z","updated_at":"2026-11-08T12:08:22.182Z","url":"https://api.seqco.de/v1/authors/20124.json"},{"id":20125,"given":"Thomas","family":"Wex","created_at":"2026-11-08T12:08:22.193Z","updated_at":"2026-11-08T12:08:22.193Z","url":"https://api.seqco.de/v1/authors/20125.json"},{"id":20126,"given":"Hashiem","family":"Hassan","created_at":"2026-11-08T12:08:22.205Z","updated_at":"2026-11-08T12:08:22.205Z","url":"https://api.seqco.de/v1/authors/20126.json"},{"id":20127,"given":"Reidwaan","family":"Ally","created_at":"2026-11-08T12:08:22.218Z","updated_at":"2026-11-08T12:08:22.218Z","url":"https://api.seqco.de/v1/authors/20127.json"},{"id":20128,"given":"Peter","family":"Malfertheiner","created_at":"2026-11-08T12:08:22.229Z","updated_at":"2026-11-08T12:08:22.229Z","url":"https://api.seqco.de/v1/authors/20128.json"}],"names":[{"id":451,"name":"Candidatus Wolinella africanus","url":"https://api.seqco.de/v1/names/451.json","uri":"https://seqco.de/i:451"}],"subjects":[]}