{"response":{"status":"ok","message_type":"publication"},"id":5002,"citation":"Hendrickson et al., 2026, International Journal of Systematic and Evolutionary Microbiology","doi":"10.1099/ijsem.0.007162","url":"https://api.seqco.de/v1/publications/5002.json","link_ext":"https://doi.org/10.1099/ijsem.0.007162","title":"Nanosynbacter lyticus gen. nov., sp. nov., an ultrasmall, obligate epibiont bacterium and the proposal of Nanosynbacteraceae fam. nov., Nanosynbacterales ord. nov. and Nanosynbacteria class nov.","journal":"International Journal of Systematic and Evolutionary Microbiology","journal_loc":"76 (5)","journal_date":"2026-05-08","pub_type":"journal-article","abstract":"\u003cjats:p\u003e\n                    The recently validly published phylum\n                    \u003cjats:italic\u003eMinisyncoccota\u003c/jats:italic\u003e\n                    (previously\n                    \u003cjats:italic\u003eCa\u003c/jats:italic\u003e\n                    . Patescibacteriota or candidate phyla radiation) had long been an enigma, with members having remained uncultivated for several decades since the first SSU ribosomal sequence was recovered. We reported on the first isolated strain of\n                    \u003cjats:italic\u003eMinisyncoccota\u003c/jats:italic\u003e\n                    ,\n                    \u003cjats:italic\u003eNanosynbacter lyticus\u003c/jats:italic\u003e\n                    type strain TM7x\n                    \u003cjats:sup\u003eT\u003c/jats:sup\u003e\n                    (ATCC TSD-290\n                    \u003cjats:sup\u003eT\u003c/jats:sup\u003e\n                    ), in 2015, using directed cultivation from human oral samples. Strain TM7x\n                    \u003cjats:sup\u003eT\u003c/jats:sup\u003e\n                    had an extremely reduced genome (705 CDS), ultra-small cell size (200–300 nm), and replicated as an obligate epibiont on the surface of another commonly found oral species:\n                    \u003cjats:italic\u003ePauljensenia odontolytica_C\u003c/jats:italic\u003e\n                    strain XH001 (host bacterium). TM7x\n                    \u003cjats:sup\u003eT\u003c/jats:sup\u003e\n                    also exhibited what has been defined as a parasitic phase, where it disrupts the membrane of the bacterial host cell, resulting in host bacteria lysis. However, free-floating, host-free TM7x\n                    \u003cjats:sup\u003eT\u003c/jats:sup\u003e\n                    cells remain viable and can re-infect fresh host bacterial cells when available. This discovery and coculture marked the first concrete evidence of how these ultrasmall organisms within the\n                    \u003cjats:italic\u003eMinisyncoccota\u003c/jats:italic\u003e\n                    survive and persist despite their reduced genomes missing\n                    \u003cjats:italic\u003ede novo\u003c/jats:italic\u003e\n                    biosynthesis of many essential compounds, including all amino acids and vitamins. This model dual species system has now allowed a deeper understanding of the TM7x–host bacterium interaction and dynamics, with over 15 publications reporting on various aspects of this strain to date. We propose the name\n                    \u003cjats:italic\u003eNanosynbacter lyticus\u003c/jats:italic\u003e\n                    gen. nov. sp. nov. for strain TM7x\n                    \u003cjats:sup\u003eT\u003c/jats:sup\u003e\n                    . We also propose\n                    \u003cjats:italic\u003eNanosynbacteraceae\u003c/jats:italic\u003e\n                    fam. nov.,\n                    \u003cjats:italic\u003eNanosynbacterales\u003c/jats:italic\u003e\n                    ord. nov. and\n                    \u003cjats:italic\u003eNanosynbacteria\u003c/jats:italic\u003e\n                    class nov. to accommodate the genus\n                    \u003cjats:italic\u003eNanosynbacter\u003c/jats:italic\u003e\n                    .\n                  \u003c/jats:p\u003e","long_citation_html":"Hendrickson et al. (2026). Nanosynbacter lyticus gen. nov., sp. nov., an ultrasmall, obligate epibiont bacterium and the proposal of Nanosynbacteraceae fam. nov., Nanosynbacterales ord. nov. and Nanosynbacteria class nov.\n\u003ci\u003eInternational Journal of Systematic and Evolutionary Microbiology\u003c/i\u003e.\n\u003ca href=\"https://doi.org/10.1099/ijsem.0.007162\" target=\"_blank\"\u003eDOI: 10.1099/ijsem.0.007162\u003c/a\u003e\n","created_at":"2026-11-12T14:33:10.555Z","updated_at":"2026-11-12T14:33:10.555Z","authors":[{"id":20151,"given":"Erik L","family":"Hendrickson","created_at":"2026-11-12T14:33:10.714Z","updated_at":"2026-11-12T14:33:10.714Z","url":"https://api.seqco.de/v1/authors/20151.json"},{"id":10591,"given":"Batbileg","family":"Bor","created_at":"2022-07-28T22:00:38.984Z","updated_at":"2022-07-28T22:00:38.984Z","url":"https://api.seqco.de/v1/authors/10591.json"},{"id":10590,"given":"Xuesong","family":"He","created_at":"2022-07-28T22:00:38.976Z","updated_at":"2022-07-28T22:00:38.976Z","url":"https://api.seqco.de/v1/authors/10590.json"},{"id":4419,"given":"Jeffrey S.","family":"McLean","created_at":"2019-04-15T19:26:31.028Z","updated_at":"2019-04-15T19:26:31.028Z","url":"https://api.seqco.de/v1/authors/4419.json"}],"names":[{"id":41786,"name":"Nanosynbacteraceae","url":"https://api.seqco.de/v1/names/41786.json","uri":"https://seqco.de/i:41786"},{"id":58065,"name":"Nanosynbacterales","url":"https://api.seqco.de/v1/names/58065.json","uri":"https://seqco.de/i:58065"},{"id":58066,"name":"Nanosynbacteria","url":"https://api.seqco.de/v1/names/58066.json","uri":"https://seqco.de/i:58066"}],"subjects":[]}